[Clinical case of mucormycosis in patient COVID-19. Case report].

The COVID-19 epidemic is being revealed from a new angle every month. In particular, with the appearance of the delta strain, mucormycosis began to manifest in some patients, which had previously been extremely rare. Mucormycosis is a rare, aggressive infection caused by filamentous fungi of the Mucorales family and associated with high morbidity and mortality rates. The main risk factors for the mucormycosis in patients with COVID-19 are diabetes mellitus and diabetic ketoacidosis, uncontrolled hyperglycemia and massive use of glucocorticoids, vascular damage, thrombosis, lymphopenia, which often occur against the background of COVID-19 and make a person vulnerable to secondary or opportunistic fungal infection. We present a clinical case of mucormycosis in a 21-year-old female patient with COVID-19-associated severe pneumonia and concomitant type I diabetes mellitus. The patient was hospitalized and received standard therapy during inpatient treatment, including glucocorticosteroids in accordance with the severity of the course of COVID-19. On the 12th day from the hospitalization, the patient's condition deteriorated significantly, and the visible changes in the skin and soft tissues of the face, characteristic of mucormycosis appeared. Despite the drug therapy correction, the patient died because of the acute respiratory failure in combination with septic fungal damage of the brain stem.

Skin manifestations in severe COVID-19. Clinical case

COVID-19 manifests itself in patients with damage to many organs and systems of the body, primarily the respiratory and cardiovascular sys-tems. At the same time, there are reports of various manifestations of skin lesions in COVID-19. We present a clinical case of skin lesions in a patient with a severe coronavirus infection. Patient G., 56 years old, was admitted to the «COVID» hospital 10 days after disease on-set. The examination revealed severe respiratory failure with a decrease in blood oxygen saturation to 80% and a specific lesion of the lungs (80%) according to computed tomography. The patient received high doses of oxygen intra-nasally, but later due to low oxygen saturation she was transferred to the intensive care unit where she underwent non-invasive ventilation. The skin lesion developed 1 month after admis-sion to the hospital and manifested itself as small grouped papular rashes on an erythematous background localized on the left thigh and pop-liteal fossa. The appearance of exanthema coincided with the 3rd episode of an increase in the level of C-reactive protein in the blood. When the patient was discharged from the hospital (on the 40th day of hospitalization) with positive dynamics of the general condition a significant decrease in skin rashes was observed. © 2021, Media Sphera Publishing Group. All rights reserved.